膝外翻与拇外翻的关联仅见于女性膝骨关节炎亚组：3582个膝与足、拇外翻患病率29.4%、调整比值比2.87，《科学报告》11月13日刊出
《科学报告》于 2026 年 11 月 13 日刊出日本研究团队的一项研究，考察膝对线、膝骨关节炎与拇外翻、拇僵硬患病率之间的关系，论文数字对象标识为 10.1038/s41598-026-76040-8。
拇外翻与拇僵硬是常见的前足畸形，但它们与膝骨关节炎及冠状面膝对线的关系此前并不清楚。研究数据来自日本 ROAD 队列的第五次调查，该队列全称为骨关节炎与骨质疏松致残研究。经排除后，共分析 3582 个膝与足。
膝对线按无骨关节炎膝得出的性别特异性股胫角阈值分为内翻、中立与外翻三组，膝骨关节炎按 Kellgren-Lawrence 分级 3 至 4 级界定。拇外翻患病率为 29.4%，拇僵硬患病率为 7.7%。
在整个队列中，拇外翻与膝骨关节炎及膝对线均无关联。但在一项探索性、用于生成假设的亚组分析中，女性膝骨关节炎患者里，外翻对线与中立对线相比与拇外翻相关，调整比值比为 2.87，95% 置信区间为 1.22 至 6.78，P 值为 0.011，而正式的对线与膝骨关节炎交互作用并不显著，P 值为 0.079。
作者据此表示，这一发现应谨慎解读。拇僵硬在多变量调整后与膝骨关节炎或膝对线均无独立关联。论文作者为 Rikyo Kuhara、Takumi Matsumoto 等人，研究于 2026 年 6 月 4 日收稿、10 月 12 日接受。
（来源：《科学报告》）
The Link Between Valgus Knee Alignment and Hallux Valgus Appears Only in a Subgroup of Women With Knee Osteoarthritis: 3,582 Knees and Feet, a Hallux Valgus Prevalence of 29.4 Percent and an Adjusted Odds Ratio of 2.87, Published in Scientific Reports on November 13
Scientific Reports published a Japanese study on November 13, 2026 examining associations between knee alignment, knee osteoarthritis and the prevalence of hallux valgus and hallux rigidus, under DOI 10.1038/s41598-026-76040-8. Hallux valgus and hallux rigidus are common forefoot deformities, but their relationships with knee osteoarthritis and coronal knee alignment remain incompletely understood. Data were obtained from the fifth survey of the Research on Osteoarthritis and Osteoporosis Against Disability cohort in Japan, known as ROAD. After exclusions, 3,582 knees and feet were analyzed. Knee alignment was classified into varus, neutral and valgus groups using sex-specific femorotibial angle thresholds derived from knees without osteoarthritis, and knee osteoarthritis was defined as Kellgren-Lawrence grade 3 to 4. Hallux valgus prevalence was 29.4 percent and hallux rigidus prevalence was 7.7 percent. In the whole cohort, hallux valgus was associated with neither knee osteoarthritis nor alignment. In an exploratory, hypothesis-generating subgroup analysis among women with knee osteoarthritis, valgus versus neutral alignment was associated with hallux valgus in an adjusted analysis, with an adjusted odds ratio of 2.87, a 95 percent confidence interval from 1.22 to 6.78 and a P value of 0.011, although the formal alignment by osteoarthritis interaction was not significant, at a P value of 0.079. The authors say the finding should therefore be interpreted cautiously. Hallux rigidus was not independently associated with knee osteoarthritis or knee alignment after multivariable adjustment. The paper, by Rikyo Kuhara, Takumi Matsumoto and co-authors, was received on June 4, 2026 and accepted on October 12, 2026.
(Source: Scientific)
来源：《科学报告》
发布：GSM·美国（发布链接）
图片来源：图：膝关节的解剖结构示意图。InjuryMap，CC BY-SA 4.0，经 Wikimedia Commons。 / Photo: InjuryMap, CC BY-SA 4.0, via Wikimedia Commons.
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