《自然·通讯》论文：单剂丙泊酚经激活外侧缰核抑制小鼠饮酒约六天
《自然·通讯》11 月 7 日发表徐州医科大学江苏省麻醉学重点实验室等机构团队的论文：静脉麻醉药丙泊酚单次给药后，可快速并持续地减少小鼠的酒精摄入，效应持续约六天。该研究为动物实验，对象为小鼠，未涉及人体试验。
论文第一作者为 Zheng Xu 与 Zhi-Jie Fan，通讯作者为 Hai-Lei Ding、Zhe Zhang、Song Zhang 与 Jun-Li Cao。作者在论文中写道，外侧缰核是调控酒精摄入的关键脑区，其神经元对丙泊酚高度敏感、反应强烈，但丙泊酚激活的缰核神经元如何调控饮酒行为此前并不清楚。研究结果显示，单剂丙泊酚对饮酒的抑制经由外侧缰核神经元的过度活动实现。
论文于 2026 年 3 月 19 日收稿、10 月 13 日接受、11 月 7 日发表，作者声明无利益冲突。研究经费来自科技创新 2030 重大项目、国家自然科学基金等。论文将外侧缰核列为减少饮酒的一个可能作用框架；抑制饮酒的持续时间、剂量关系与机制细节以论文正文为准，本稿只转述其已发表的摘要与作者信息，不作人体层面的推论。
Nature Communications Paper: A Single Dose of Propofol Suppresses Alcohol Drinking in Mice for About Six Days via Lateral Habenula Activation
A paper published in Nature Communications on November 7 by teams including the Jiangsu Province Key Laboratory of Anesthesiology at Xuzhou Medical University reports that a single dose of the intravenous anesthetic propofol rapidly and persistently reduces alcohol consumption in mice, with the effect lasting approximately six days. The study was conducted in mice; no human trial is reported.
The paper's first authors are Zheng Xu and Zhi-Jie Fan, with Hai-Lei Ding, Zhe Zhang, Song Zhang and Jun-Li Cao as corresponding authors. The authors write that the lateral habenula is a key brain region regulating alcohol consumption and that its neurons show high sensitivity and responsiveness to propofol, while whether and how propofol-activated habenular neurons regulate alcohol drinking was previously unknown. The results show the suppression of drinking is mediated by hyperactivity of lateral habenula neurons.
The paper was received on March 19, 2026, accepted on October 13, 2026 and published on November 7, 2026; the authors declare no competing interests. Funding came from the Sci-Tech Innovation 2030 Major Project and the National Natural Science Foundation of China, among other sources. The authors present the lateral habenula as a promising framework for reducing drinking; this report relays only the published abstract and author information and draws no human-level conclusion.
来源：《自然·通讯》
发布：GSM·美国（发布链接）
图片来源：图：实验室小鼠（资料图）。Openverse／Rawpixel，CC0。 / Photo: A laboratory mouse (file photo). Openverse / Rawpixel, CC0.
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