《自然·通讯》11月6日论文：沙门氏菌两类血清型用相反的入侵前策略感知并侵入人体肠道上皮，McKenna、Geier 与 Monack 团队发表
《自然·通讯》11 月 6 日发表 McKenna、Geier 与 Monack 等作者的论文，比较肠道沙门氏菌（Salmonella enterica）两类血清型在侵入人体肠道上皮之前采取的策略。论文指出，泛宿主型（generalist）血清型引起胃肠炎，人限制型（human-restricted）血清型引起伤寒热，两类病原体面对的是同一道肠道上皮屏障，但采取的入侵前策略彼此相反。
按论文摘要，两类血清型在感知肠道上皮与发起侵入的方式上方向相反：一类与另一类在接近上皮、识别目标与启动侵入的顺序与方式上呈镜像式差异。作者据此说明，同一物种内部的血清型分化不仅体现在致病表现（胃肠炎与伤寒热）上，也体现在感染最早期与宿主组织接触的环节上。
该论文为正式发表的同行评审论文，通讯作者为 Denise M. Monack，第一作者为 Joy A. McKenna，Benedikt Geier 为共同作者。
Nature Communications Paper of November 6: Two Types of Salmonella Serovars Use Opposing Pre-Invasion Strategies to Sense and Invade Human Intestinal Epithelium, From McKenna, Geier and Monack
A paper published in Nature Communications on November 6 by McKenna, Geier, Monack and colleagues compares the strategies that two types of Salmonella enterica serovars use before invading human intestinal epithelium. The authors note that generalist serovars cause gastroenteritis while human-restricted serovars cause typhoid fever, and that the two types use opposing pre-invasion strategies to sense and invade the human intestinal epithelium.
According to the paper's abstract, the two serovar types move in opposite directions in how they approach the epithelium, recognize their target and initiate invasion, a mirror-image difference at the earliest stage of infection. The authors present this as evidence that serovar divergence within the species shows up not only in disease presentation — gastroenteritis versus typhoid fever — but also in the first contact with host tissue.
The paper is a formally published, peer-reviewed article. Its first author is Joy A. McKenna, with Benedikt Geier as co-author and Denise M. Monack as corresponding author. Experimental data, samples and mechanistic detail are as given in the journal text; this report relays only the published abstract's comparison of the two strategies and draws no clinical conclusion.
来源：《自然·通讯》
发布：GSM·美国（发布链接）
图片来源：图：沙门氏菌显微图。Wikimedia Commons 供图，公共领域，经 Wikimedia Commons。 / Photo: Salmonella bacteria under a microscope. By Wikimedia Commons 供图, public domain, via Wikimedia Commons.
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