印度912例胆囊癌病例对照研究：血清金属混合物指数每升一级，风险比值比达6.19
一项11月14日刊于《科学报告》（Scientific Reports）的病例对照研究，考察了血清微量元素与胆囊癌风险的关联。研究在印度 Tata Memorial Hospital 招募了912名胆囊癌病例与1140名访客对照，检测了血清中非必需元素（铬、镍、砷、镉、铅、铀）与必需元素（锰、铜、硒）的浓度，论文数字对象标识为 10.1038/s41598-026-77322-x。
研究发现，铜、锰、镉与铀呈显著的非线性关联。金属混合物方面，加权分位数和（WQS）指数每上升一个单位，胆囊癌风险的比值比为6.19（95%置信区间4.84至7.95），其中权重贡献最大的是铜，约占60%，其次是镉约26%、锰约13%。在内部验证数据中，该关联仍然显著，比值比为2.71（95%置信区间2.26至3.25）。
胆囊癌是一种少见但侵袭性强的胆道恶性肿瘤，发病率有明显的地域差异，印度北部、东部与东北部地区报告的发病率较高。
Indian case-control study of 912 gallbladder cancer cases: one-unit rise in serum metal mixture index linked to odds ratio of 6.19
A case-control study published on November 14 in Scientific Reports investigated the association of serum trace elements with gallbladder cancer risk. The hospital-based study enrolled 912 gallbladder cancer cases and 1,140 visitor controls at Tata Memorial Hospital in India, measuring serum concentrations of non-essential elements (chromium, nickel, arsenic, cadmium, lead and uranium) and essential elements (manganese, copper and selenium). The paper's DOI is 10.1038/s41598-026-77322-x.
The study found strong non-linear associations for copper, manganese, cadmium and uranium. For the metal mixture, a one-unit increase in the weighted quantile sum (WQS) index was associated with increased gallbladder cancer risk, with an odds ratio of 6.19 (95 percent confidence interval 4.84 to 7.95). The highest weight was contributed by copper, at about 60 percent, followed by cadmium at about 26 percent and manganese at about 13 percent. In an internal validation dataset, the association remained significant, with an odds ratio of 2.71 (95 percent confidence interval 2.26 to 3.25).
Gallbladder cancer is a rare yet aggressive biliary tract malignancy with marked geographic variation in incidence, with particularly high rates reported across northern and eastern India and parts of north-eastern India.
来源：科学报告
发布：GSM·美国（发布链接）
图片来源：图中是位于孟买的 Tata Memorial Hospital 的 Homi Bhabha 楼，该研究在此招募病例与对照。Reetesh Chaurasia, CC BY-SA 4.0, via Wikimedia Commons
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