芍药苷在高脂饮食小鼠中减轻肥胖 100与200毫克每公斤组终体重分别降低5.6%和9.8%
《科学报告》11月14日发表一项芍药苷与肥胖的动物研究。芍药苷是一种天然单萜苷，此前其对白色脂肪组织褐变的作用尚不清楚。促进白色脂肪褐变被视为提高能量消耗、改善代谢稳态的一种潜在策略。
研究以高脂饮食诱导 C57BL/6 小鼠肥胖，随后口服给予芍药苷100或200毫克每公斤，并用 AMPK 药理学抑制手段进一步考察 AMPK/SIRT3 信号通路是否参与其中。
与高脂饮食组相比，芍药苷处理以剂量依赖方式减轻肥胖和代谢异常：100毫克每公斤组终体重降低5.6%，200毫克每公斤组降低9.8%。芍药苷还减轻脂肪细胞肥大，并提高腹股沟白色脂肪组织中 UCP1、PGC-1α 和 PRDM16 等褐变相关标志物的表达。
在分化的 3T3-L1 脂肪细胞中，芍药苷减少脂质积累、提高褐变标志物表达并激活 AMPK/SIRT3 信号，而抑制 AMPK 后这些作用减弱。作者据此表示，芍药苷的作用可能与激活 AMPK/SIRT3 信号通路有关。论文由 Sun、Wang、Ni 等作者发表，研究对象为小鼠与细胞模型。
Paeoniflorin Reduces Obesity in High-Fat-Diet Mice, Final Body Weight Down 5.6% and 9.8% at Two Doses
Scientific Reports on November 14 published an animal study of paeoniflorin (PF) and obesity. PF is a natural monoterpene glycoside whose effects on white adipose tissue (WAT) browning were previously unclear. Inducing WAT browning has emerged as a potential strategy to enhance energy expenditure and improve metabolic homeostasis.
Obesity was induced in C57BL/6 mice by high-fat diet (HFD) feeding, followed by oral administration of PF at 100 or 200 mg/kg. The potential involvement of the AMPK/SIRT3 signaling pathway was investigated using pharmacological inhibition of AMPK.
PF treatment significantly attenuated HFD-induced obesity and metabolic abnormalities in a dose-dependent manner. Compared with the HFD group, final body weight was reduced by 5.6 percent at 100 mg/kg and by 9.8 percent at 200 mg/kg. PF also reduced adipocyte hypertrophy and increased expression of the browning-related markers UCP1, PGC-1α and PRDM16 in inguinal white adipose tissue.
In differentiated 3T3-L1 adipocytes, PF reduced lipid accumulation, enhanced browning-related marker expression and activated AMPK/SIRT3 signaling, whereas pharmacological inhibition of AMPK attenuated these effects. The authors conclude the effects may be associated with activation of the AMPK/SIRT3 pathway. The paper, by Sun, Wang, Ni and colleagues, is based on mouse and cell models.
来源：《科学报告》
发布：GSM·美国（发布链接）
图片来源：图：显微镜下的脂肪组织（资料图）。来源：Lumihell，Wikimedia Commons，CC BY 4.0。 / Photo: Adipose tissue under a microscope (file photo). Source: Lumihell, Wikimedia Commons, CC BY 4.0.
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