美国国立卫生研究院向洛杉矶 Cedars-Sinai 拨款逾1200万美元：研究病毒感染如何引发肺纤维化
洛杉矶 Cedars-Sinai 医疗中心11月13日宣布，该中心获得美国国立卫生研究院（NIH）下属国家心肺血液研究所（NHLBI）逾1200万美元拨款，为期五年，研究病毒感染如何引发不可逆的肺纤维化，也就是肺组织瘢痕化。
据该中心说明，这项拨款汇集12名研究者，下设3个研究项目与4个共享核心平台。Cedars-Sinai 的 Ping Chen 团队研究病毒如何重编程肺干细胞；弗吉尼亚大学 Jie Sun 团队研究免疫微环境在纤维化中的作用；Cedars-Sinai 的 Xue Liu 研究相关的细胞信号通路。三个团队将共享数据与样本，拼出从感染到瘢痕形成的完整链条。
肺纤维化是一类进行性肺病，患者肺组织逐渐变硬、失去弹性，目前尚无根治办法，部分患者在呼吸道病毒感染后出现或加重。研究团队表示，弄清病毒触发纤维化的机制，是找到阻断药物靶点的前提。
（来源：Cedars-Sinai 医疗中心）
NIH Awards Cedars-Sinai Over $12 Million to Study How Viral Infections Trigger Pulmonary Fibrosis
Cedars-Sinai in Los Angeles announced on November 13 that it has received more than $12 million over five years from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), to study how viral infections trigger irreversible pulmonary fibrosis, the scarring of lung tissue.
The award brings together 12 investigators across three research projects and four shared cores. A Cedars-Sinai team led by Ping Chen, MD, PhD, studies how viruses reprogram lung stem cells; Jie Sun's team at the University of Virginia examines the immune microenvironment in fibrosis; and Cedars-Sinai's Xue Liu studies the cell-signaling pathways involved. The groups will share data and samples to map the full chain from infection to scarring.
Pulmonary fibrosis is a progressive lung disease in which tissue stiffens and loses elasticity; there is no cure, and some patients develop or worsen after respiratory viral infections. The researchers say understanding how viruses set fibrosis in motion is a prerequisite for finding drug targets that can block it.
(Source: Cedars-Sinai)
来源：Cedars-Sinai 医疗中心
发布：GSM·美国（发布链接）
图片来源：Wikimedia Commons：File:Cedars-Sinai Los Angeles Mark Goodson Building Los Angeles County California 2024 Feb.jpg（开放授权）
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