全血NAD水平不随健康衰老下降、与心血管疾病相关：1068名成年人研究发表于《自然-代谢》
立陶宛维尔纽斯大学研究团队在《自然-代谢》（Nature Metabolism）发表研究，分析 1068 名成年人的全血 NAD（烟酰胺腺嘌呤二核苷酸）水平，共完成 1340 次测量，样本包括健康者与慢性病患者，采用标准化干血斑样本。结果显示，健康成年人全血 NAD 不随年龄下降：男性保持稳定，女性略有上升；而慢性病患者 NAD 较低，其中与心血管疾病、尤其是高血压的关联最清晰。
研究负责人 Dalius Ratautas 表示，多年来的流行说法是 NAD 随衰老下降、需要补充，但健康成年人血液中并未出现这种普遍下降。研究团队同时强调，该结果不确立 NAD 与心血管疾病之间的因果关系，也未证明补充 NAD 可预防或治疗心血管疾病；下一步将检验全血 NAD 能否用于预测心血管风险。论文 DOI 为 10.1038/s42255-026-01660-3，第一作者为 Diana Romenskaja-Avgul。
图中是立陶宛维尔纽斯大学图书馆内景
Study of 1,068 Adults Finds Whole-Blood NAD Levels Do Not Decline With Healthy Aging but Track Cardiovascular Disease, Published in Nature Metabolism
Researchers at Vilnius University in Lithuania, publishing in Nature Metabolism, analysed whole-blood NAD (nicotinamide adenine dinucleotide) levels in 1,068 adults, conducting 1,340 measurements using dried blood spot samples collected under standardised conditions, in a cohort including healthy individuals and people with chronic diseases. Among healthy adults, whole-blood NAD did not decline with age, remaining stable in men and showing a modest but statistically significant increase in women. NAD levels were lower in people with cardiovascular disease, with the clearest differences among those with hypertension.
Dr Dalius Ratautas, who led the research, said the prevailing narrative that NAD declines with age and therefore needs to be restored is not what happens in the blood of healthy adults. The researchers emphasise that the findings do not establish a cause-and-effect relationship between NAD levels and cardiovascular disease, and do not demonstrate that increasing NAD through supplementation can prevent or treat cardiovascular disease or hypertension. The paper, by Diana Romenskaja-Avgul and colleagues, has DOI 10.1038/s42255-026-01660-3.
来源：《自然-代谢》
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图片来源：图中是立陶宛维尔纽斯大学图书馆内景。Wikimedia Commons — Scotch Mist, CC BY-SA 4.0
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