NIH姐妹研究：血液中PFOA与PFOS水平最高组侵袭性乳腺癌发生率高67%与93%，与总体乳腺癌无明确关联
美国国立卫生研究院（NIH）11月5日发布的分析显示，血液中两种常见「永久性化学物质」PFOA 与 PFOS 水平较高的女性，患雌激素受体阴性（ER阴性）乳腺癌的比例更高。研究发表于《临床肿瘤学杂志》，由 NIH 下属的国家环境健康科学研究所牵头的「姐妹研究」完成。
研究人员检测了女性在确诊癌症多年前采集的血液样本中的17种 PFAS。结果显示，PFOA 水平最高组与最低组相比，ER阴性乳腺癌发生率高出67%；PFOS 最高组高出93%，接近一倍。ER阴性肿瘤不依赖雌激素生长，往往更具侵袭性，也无法用激素疗法治疗。姐妹研究在2003至2009年间招募了50884名35至74岁的女性，来自美国与波多黎各，每位参与者都有一位被诊断过乳腺癌的姐妹。
研究团队特别说明，这项研究没有发现这两种化学物质与总体乳腺癌风险之间存在明确关联，信号只出现在 ER阴性这一亚型上；同时这是观察性研究，显示的是关联而非因果，结论还需要在其他人群中验证。（来源：美国国立卫生研究院）
NIH Sister Study: Highest PFOA Levels Linked to a 67% Higher Rate of Aggressive Breast Cancer and PFOS to 93%, With No Clear Association Overall
Women with higher blood levels of two common "forever chemicals," PFOA and PFOS, were more likely to develop estrogen receptor-negative (ER-negative) breast cancer, according to a National Institutes of Health analysis released November 5. The study, published in the Journal of Clinical Oncology, was carried out within the Sister Study, led by NIH's National Institute of Environmental Health Sciences.
Researchers measured 17 PFAS in blood samples collected years before any cancer diagnosis. Women in the group with the highest PFOA levels had a 67% higher rate of ER-negative breast cancer than those in the lowest group; for PFOS the rate was 93% higher, nearly double. ER-negative tumors do not rely on estrogen to grow, tend to be more aggressive and cannot be treated with hormone therapy. The Sister Study enrolled 50,884 women ages 35 to 74 in the United States and Puerto Rico between 2003 and 2009, each of whom had a sister diagnosed with breast cancer.
The researchers emphasize two limits: the study found no clear association between the two chemicals and breast cancer risk overall, with the signal confined to the ER-negative subtype, and the design is observational, showing an association rather than proof of cause, so the findings need confirmation in other populations. (Source: National Institutes of Health)
来源：美国国立卫生研究院
发布：GSM·美国（发布链接）
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