柠檬汁催化加机械研磨合成吡唑香豆素类化合物 终产物产率 90% 至 92%
11 月 14 日发表于《科学报告》的一项研究提出用柠檬汁催化、机械研磨合成吡唑香豆素类化合物的绿色方法。研究作者为开罗大学的 Anhar Abdel-Aziem。新鲜柠檬汁含 5% 至 7% 的柠檬酸，实验中取 10 毫升柠檬汁，煮沸约 10 分钟后沉淀使用。
中间体化合物 4 与化合物 5 的产率均为 92%，原子经济性分别为 96.5% 与 95.9%。与传统方法需要 1 至 2 小时相比，机械研磨 5 至 10 分钟即可完成反应，终产物产率为 90% 至 92%。
以化合物 7a 为例，其原子经济性为 77.78%，E-factor 为 0.397。
Lemon Juice Catalysis and Mechanical Grinding Yield Pyrazole-Coumarin Compounds at 90% to 92%
A study published November 14 in Scientific Reports presents a green method for synthesizing pyrazole-coumarin compounds using lemon juice as a catalyst and mechanical grinding. The author is Anhar Abdel-Aziem of Cairo University. Fresh lemon juice contains 5 to 7 percent citric acid; in the experiments, 10 milliliters of lemon juice were boiled for about 10 minutes and the precipitate was used.
The intermediate compounds 4 and 5 were each obtained in 92 percent yield, with atom economies of 96.5 percent and 95.9 percent respectively. Compared with the one to two hours required by conventional methods, mechanical grinding completed the reaction in 5 to 10 minutes, and final product yields were 90 to 92 percent.
For compound 7a, the atom economy was 77.78 percent and the E-factor was 0.397.
来源：《科学报告》
发布：GSM·美国（发布链接）
图片来源：图：结在柠檬树上的柠檬果实。来源：Bj.schoenmakers，Wikimedia Commons，CC0 1.0。 / Photo: Lemons growing on a lemon tree. Source: Bj.schoenmakers, Wikimedia Commons, CC0 1.0.
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