基孔肯雅病毒多表位疫苗完成计算设计 预测抗原性评分 0.524
11 月 14 日发表于《科学报告》的一项研究报道了基孔肯雅病毒多表位疫苗的计算设计。研究作者为 Hayat、Gul 与 D'Elia 等人，以病毒结构多聚蛋白为靶标，筛选 B 细胞、MHC-I 与 MHC-II 表位，并逐项评估抗原性、免疫原性、致敏性与毒性。
最终构建体的预测抗原性评分为 0.524，预测无致敏性、无毒性。作者说明，该疫苗目前仅为计算设计，尚需体外与体内实验确认。本研究资助项目编号为 ORF-2026-189，研究不涉及人体受试者。
Multi-Epitope Chikungunya Vaccine Completes Computational Design With Predicted Antigenicity Score of 0.524
A study published November 14 in Scientific Reports reports the computational design of a multi-epitope vaccine against chikungunya virus. The authors, Hayat, Gul, D'Elia, and colleagues, targeted the viral structural polyprotein, screening B-cell, MHC-I, and MHC-II epitopes and assessing each for antigenicity, immunogenicity, allergenicity, and toxicity.
The final construct had a predicted antigenicity score of 0.524 and was predicted to be non-allergenic and non-toxic. The authors state that the vaccine is a computational design only and still requires in vitro and in vivo confirmation. The work was funded under project number ORF-2026-189 and involved no human subjects.
来源：《科学报告》
发布：GSM·美国（发布链接）
图片来源：图：一只雌性埃及伊蚊正在宿主皮肤上吸血，埃及伊蚊是基孔肯雅病毒的传播媒介之一。来源：CDC / James Gathany，Wikimedia Commons，Public domain。 / Photo: A female Aedes aegypti mosquito feeding on host skin; the species is one of the vectors of chikungunya virus. Source: CDC / James Gathany, Wikimedia Commons, Public domain.
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