动态调节压力测试区分亚临床圆锥角膜：180人三组各60人、动态扩张指数灵敏度98.3%特异度96.7%，《科学报告》11月12日刊出
《科学报告》2026年11月12日刊出一项前瞻性诊断准确性研究，用动态调节压力测试做亚临床圆锥角膜的早期检测。研究结合Scheimpflug-Placido成像与眼前节光学相干断层扫描，观察受检者在调节用力时眼前节的变化，共纳入180名参与者、每人一只眼，分为三组，即双侧亚临床圆锥角膜组60人、扩张很不对称而对侧眼临床未受累组60人与健康对照组60人，三组年龄匹配。作者为Burhan Başkan与Yusuf Evcimen，论文数字对象标识为10.1038/s41598-026-79398-x。
研究在数据收集后由本数据集导出两个复合指数，即动态扩张指数与角膜厚度重分布指数，两者均非预先设定。期刊摘要报告，在6屈光度调节下，亚临床圆锥角膜眼在每一项主要结局上都比对照眼形变更明显，例如前房深度变化为负0.114加减0.021毫米对负0.069加减0.015毫米，下颞侧曲率变化为1.76加减0.27屈光度对0.66加减0.17屈光度，两项的p值均小于0.001。
摘要报告，动态扩张指数区分亚临床圆锥角膜眼与对照眼的灵敏度为98.3%、特异度为96.7%，曲线下面积为0.995，95%置信区间为0.989至1.000。作者同时明确指出，全部估计都在同一数据集中导出与评估，因此偏乐观，该指数应理解为筛查用的复合指标而非生物力学参数，临床使用前需要在独立队列中做外部验证。
（来源：《科学报告》）
Dynamic Accommodative Stress Testing Separates Subclinical Keratoconus in a 180-Person Study: A Dynamic Ectasia Index Sensitivity of 98.3 Percent and Specificity of 96.7 Percent, in Scientific Reports on November 12
A prospective diagnostic accuracy study published in Scientific Reports on November 12, 2026, used dynamic accommodative stress testing for early detection of subclinical keratoconus. Combining Scheimpflug-Placido imaging with anterior segment optical coherence tomography, the study examined anterior segment changes during accommodative effort in 180 participants, one eye each, allocated to three age-matched groups of 60, namely bilateral subclinical keratoconus, very asymmetric ectasia with clinically unaffected fellow eyes, and healthy controls. The authors are Burhan Başkan and Yusuf Evcimen, and the paper carries digital object identifier 10.1038/s41598-026-79398-x. Two composite indices, the Dynamic Ectasia Index and the Corneal Thickness Redistribution Index, were derived from the dataset after data collection and were not prespecified. The journal abstract reported that at 6 diopters, subclinical keratoconus eyes deformed more than controls in every primary outcome, including an anterior chamber depth change of minus 0.114 plus or minus 0.021 millimeters versus minus 0.069 plus or minus 0.015 millimeters, and an inferotemporal curvature change of 1.76 plus or minus 0.27 diopters versus 0.66 plus or minus 0.17 diopters, both with p below 0.001. The abstract reported that the Dynamic Ectasia Index separated subclinical keratoconus from control eyes with 98.3 percent sensitivity and 96.7 percent specificity, with an area under the curve of 0.995 and a 95 percent confidence interval of 0.989 to 1.000. The authors stated plainly that all estimates were derived and evaluated in the same dataset and are therefore optimistic, that the indices should be interpreted as screening composites rather than biomechanical parameters, and that external validation in independent cohorts is required before clinical use.
(Source: Scientific)
来源：《科学报告》
发布：GSM·美国（发布链接）
图片来源：图：一名眼科医生正在为受检者做眼部检查。Tony Webster，CC BY 2.0，经 Wikimedia Commons。 / Photo: Tony Webster, CC BY 2.0, via Wikimedia Commons.
GSM Global · 本篇英文版 English edition of this story
