GLP-1 受体激动剂使用与重复结肠镜风险：《科学报告》TriNetX 全球网络回顾性队列研究 11 月 11 日刊出
中国台湾新北市 — 《科学报告》2026 年 11 月 11 日刊出一项真实世界队列研究，题为 GLP-1 受体激动剂使用与重复结肠镜风险的关联。论文作者来自辅仁大学附设医院、台北荣民总医院与阳明交通大学等机构，通讯作者为 Chun-Ying Wu。
研究背景方面，胰高血糖素样肽-1 受体激动剂越来越多地用于糖尿病与肥胖治疗，其对胃肠动力的影响引发了对结肠镜检查结果的关注。研究团队据此评估 GLP-1 受体激动剂使用与重复结肠镜之间的关联，并对检查前停药间隔做了探索性分析。
研究方法方面，这是一项使用 TriNetX 全球协作网络数据的回顾性队列研究，分析对象限定为 18 至 90 岁成年人。由于研究仅分析 TriNetX 研究网络的去标识化数据，辅仁大学附设医院机构审查委员会认定该研究免于审查，知情同意要求亦获豁免；该研究为回顾性观察研究，未注册为临床试验。
研究资助来自辅仁大学附设医院、台湾科技主管部门与卫生福利主管部门的相关计划编号，作者声明无利益冲突。本稿只报道研究设计与已刊出的研究框架，论文的效果量数字以期刊原文为准，读者引用时请回原文核对。本研究为观察性设计，关联不等于因果。
GLP-1 Receptor Agonist Use and Risk of Repeat Colonoscopy: Scientific Reports Publishes a TriNetX Global Network Retrospective Cohort Study on November 11
New Taipei, Taiwan — Scientific Reports published a real-world cohort study on November 11, 2026, titled Association between GLP-1 receptor agonist use and risk of repeat colonoscopy. The authors are affiliated with Fu Jen Catholic University Hospital, Taipei Veterans General Hospital and National Yang Ming Chiao Tung University, among other institutions, with correspondence to Chun-Ying Wu.
Glucagon-like peptide-1 receptor agonists are increasingly used for diabetes and obesity, and their effects on gastrointestinal motility have raised concern about colonoscopy outcomes. The team evaluated the association between GLP-1 receptor agonist use and repeat colonoscopy and performed exploratory analyses of pre-procedural discontinuation intervals.
The study is a retrospective cohort study using the TriNetX Global Collaborative Network, restricted to adults aged 18 to 90 years. Because only de-identified data from the TriNetX research network were analysed, the institutional review board of Fu Jen Catholic University Hospital deemed the study exempt from review and waived informed consent. The study was not registered as a clinical trial.
Funding came from Fu Jen Catholic University Hospital and Taiwanese science and health authorities under the grant numbers listed in the paper, and the authors declared no competing interests. This report covers the study design and published framework only; effect-size figures should be taken from the journal text itself. The design is observational, and association does not establish causation.
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图片来源：图：图中是一台结肠镜模拟训练设备。图中是结肠镜模拟器的实物照片，为结肠镜题材通用配图，非本研究设备。division, CSIRO，CC BY 3.0，经Wikimedia Commons。 / Photo: file photo. division, CSIRO, CC BY 3.0, via Wikimedia Commons.
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