登革病毒株基因组多样性高：411 例指示病例覆盖 7 国 30 个站点、《科学报告》称四种血清型在拉美与亚太共同流行
比利时 — 《科学报告》2026 年 11 月 11 日刊出一项登革病毒基因组研究，作者为 Van Eygen、Vijgen、Hong 等人。研究数据来自 mosnodenvir 预防的二期临床试验，该试验 2023 至 2024 年在亚太与拉丁美洲的登革流行地区进行，登记号为 NCT05201794。
样本方面，该研究共纳入 411 例登革指示病例，登革血清型以逆转录聚合酶链反应确定；其中 150 例指示病例做了全基因组测序，样本代表了 7 个国家 30 个站点在不同时间观察到的登革血清型。
结果方面，四种登革血清型在拉丁美洲与亚太两个地区均被观察到共同流行。总体上，1 型登革病毒为优势血清型，占 51.1%，基因型分布有明显的地域差异：拉丁美洲以 1 型基因型 V 为主，亚太地区以 1 型基因型 I 与 IV 为主。
研究还发现，2023 至 2024 年间，3 型与 4 型登革病毒株在拉丁美洲的流行有所增加。按时间分辨的系统发育分析显示，该研究捕捉到了 2023 至 2024 年间在拉丁美洲与亚太地区流行的当代登革病毒多样性的广泛横截面。本稿数字均以论文摘要正文为准。
Dengue Virus Strains Show High Genomic Diversity: 411 Index Cases across 30 Sites in 7 Countries, Scientific Reports Finds All Four Serotypes Cocirculating in Latin America and Asia-Pacific
Belgium — Scientific Reports published a dengue virus genomic study on November 11, 2026, by Van Eygen, Vijgen, Hong and colleagues. The data come from the Phase 2 clinical trial of mosnodenvir prophylaxis, registered as NCT05201794, conducted in endemic regions of Asia-Pacific and Latin America in 2023 to 2024.
The study involved 411 dengue index cases, with serotypes determined using RT-PCR. Whole-genome sequencing was conducted for a subset of 150 index cases representing the dengue serotypes observed over time at 30 sites across 7 countries.
Cocirculation of all four dengue serotypes was observed in both Latin America and the Asia-Pacific region. Overall, dengue serotype 1 was predominant at 51.1 percent, with significant geographical variation in genotype distribution: serotype 1 genotype V in Latin America versus genotypes I and IV in the Asia-Pacific region.
The study also identified increased circulation of serotype 3 and serotype 4 strains in Latin America during 2023 to 2024. Time-resolved phylogenetic analyses show the study captured a broad cross-section of contemporary dengue diversity circulating across Latin America and the Asia-Pacific region during that period. All figures in this report follow the abstract of the paper.
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图片来源：图：图中是一只埃及伊蚊正在叮咬人手。图中是埃及伊蚊的实物照片，埃及伊蚊是登革病毒的主要传播媒介之一。Original author: US Department of Agriculture; then denoised，Public domain，经Wikimedia Commons。 / Photo: file photo. Original author: US Department of Agriculture; then denoised, Public domain, via Wikimedia Commons.
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