密歇根大学牵头联盟获 NIH 最高5,200万美元资助：追踪1,500名婴幼儿，破解呼吸道感染康复差异
密歇根大学医学中心（Michigan Medicine）10月20日宣布，由该校牵头的一个多中心研究联盟已获美国国立卫生研究院（NIH）批准，将获得最高5,200万美元联邦资助，研究为什么病毒性下呼吸道感染对婴幼儿的影响差异巨大：有些孩子完全康复，有些却发展为重症或留下哮喘等长期问题。
该研究将招募1,500名因病毒性下呼吸道感染住院的0至24个月婴幼儿，病种包括毛细支气管炎、肺炎和儿童急性呼吸窘迫综合征，并随访至少到孩子4至5岁。研究内容包括详细的临床评估、肺功能测试、影像检查、环境暴露测量、活动与睡眠监测，以及先进的分子分析。
项目负责人、密歇根大学儿科学系教授兼研究副主任、C.S. Mott 儿童医院儿科重症医学科主任 Peter Mourani 医生表示，目前当一名幼儿因病毒性呼吸道感染住院时，医生很难预测其病程走向；这项研究旨在理解哪些孩子会完全康复、哪些会反复感染、哪些会发展为持续性呼吸道疾病，并找出何时以及如何进行干预。密歇根大学位于美国密歇根州 Ann Arbor。
University of Michigan-Led Consortium Wins Up to $52 Million in NIH Funding: Study Will Follow 1,500 Infants to Learn Why Respiratory Infections Affect Children Differently
Michigan Medicine announced on October 20 that a multicenter research consortium led by the University of Michigan has been approved for up to $52 million in funding from the National Institutes of Health (NIH) to study why viral lower respiratory tract infections affect young children so differently — why some recover fully while others develop severe illness or lasting problems such as asthma.
The study will enroll 1,500 children ages 0 to 24 months who are hospitalized with viral lower respiratory tract infections, including bronchiolitis, pneumonia, and pediatric acute respiratory distress syndrome, and follow them through at least ages four to five. It will combine detailed clinical assessments with lung function testing, imaging, environmental exposure measurements, activity and sleep monitoring, and advanced molecular analyses.
"Right now, when a young child is hospitalized with a viral respiratory infection, we have very limited ability to predict what their trajectory will be," said principal investigator Dr. Peter Mourani, professor and associate chair of research in the Department of Pediatrics and division director of pediatric critical care medicine at U-M Health C.S. Mott Children's Hospital in Ann Arbor, Michigan. The study is designed to identify which children recover completely, which have repeated problems with later infections, and which go on to persistent respiratory disease — and when and how clinicians might intervene.
来源：GSM·美国（原文链接）
图片来源：密歇根大学 C.S. Mott 儿童医院（资料图，摄于 Ann Arbor）。照片：Dwight Burdette 摄，CC BY 3.0，经维基共享资源。 / C.S. Mott Children's Hospital at the University of Michigan in Ann Arbor (file photo). Photo by Dwight Burdette, CC BY 3.0, via Wikimedia Commons.
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