Salt Lake City 的 Myriad Genetics 公布癌症 MRD 检测新数据：将亮相欧洲肿瘤大会
总部位于犹他州 Salt Lake City 的分子诊断公司 Myriad Genetics（NASDAQ: MYGN）10月22日公布了正在进行的 MONSTAR-SCREEN-3 研究的新数据，展示其基于全基因组测序的 Precise MRD 平台在可切除结直肠癌与胰腺癌患者中实现超灵敏分子残留病灶（MRD）检测的潜力。
在可切除结直肠癌患者中，术后一个月检测到的循环肿瘤 DNA（ctDNA）与疾病进展强烈相关：在所有观察到的复发病例中，ctDNA 均在临床复发之前被检出，中位提前时间为四个月，且超过一半的术后 ctDNA 阳性患者是在低于百万分之 100 的超灵敏水平下被检出的。在胰腺癌方面，所有可评估患者均成功构建个性化检测 panel，其中一半达到最高的 1000 个变异位点；术后一个月检出 MRD 的患者，其无复发生存期显著差于未检出者。
公司首席科学官 Dale Muzzey 表示，这些数据进一步证明 Precise MRD 有望为复发难以早期发现的癌种带来更灵敏、更个性化的术后监测：通过全基因组测序构建个体化检测 panel，可在极低水平检测 ctDNA，帮助临床医生更早识别复发风险并做出更明智的患者管理决策。相关研究结果将于 10月25日在 2026 年欧洲肿瘤内科学会（ESMO）大会上公布。Myriad Genetics 是分子诊断与精准医疗领域的企业，其检测用于评估疾病发生与进展风险并指导治疗决策。
Salt Lake City's Myriad Genetics Releases New Cancer MRD Data: Results Head to ESMO Congress
Salt Lake City, Utah-based Myriad Genetics, Inc. (NASDAQ: MYGN) on October 22 released new data from the ongoing MONSTAR-SCREEN-3 study, showing the potential of its whole-genome sequencing-based Precise MRD platform for ultra-sensitive molecular residual disease detection in patients with resectable colorectal and pancreatic cancers.
In resectable colorectal cancer, ctDNA detected one month after surgery was strongly associated with disease progression; ctDNA was detected before clinical recurrence in all observed recurrence events, with a median lead time of four months, and more than half of post-surgical ctDNA-positive patients were identified below 100 parts per million. In pancreatic cancer, personalized panels were created for all evaluable patients, half reaching the maximum 1,000 variants, and patients with MRD detected one month after surgery had significantly worse recurrence-free survival.
Chief Scientific Officer Dale Muzzey said the data reinforce the potential of Precise MRD to bring more sensitive, personalized monitoring to cancers where recurrence is hard to identify early. The findings will be presented at the ESMO Congress 2026 on October 25.
来源：GSM·美国（原文链接）
图片来源：图片来源：Wikimedia Commons，CC BY 2.0，作者 Mangoman88（Salt Lake City 天际线实景） | Photo: Wikimedia Commons, CC BY 2.0, by Mangoman88 (Salt Lake City skyline)
